Sebastian Thiel

• In Silico simulation of biological systems is an important sub area of computational biology (system biology), and becomes more and more an inherent part for research. Therefore, different kinds of software tools are required. At present, a multitude of tools for several areas exists, but the problem is that most of the tools are essentially application specific and cannot be combined. For instance, a software tool for the simulation of biochemical processes is not able to interact with tools for the morphology simulation and vice versa. In order to obtain realistic results with computer-aided simulations it is important to regard the biological system in its entirety. The objective is to develop a software framework, which provides an interface structure to combine existing simulation tools, and to offer an interaction between all affiliated systems. Consequently, it is possible to re-use existing models and simulation programs. Additionally, dependencies between those can be defined. The system is designed to interoperate as an extendable architecture for various tools. The thesis shows the usability and applicability of the software and discusses potential improvements.