Master's Thesis
Tractography on HARDI data
(2011)
Diffusion weighted imaging is an important modality in clinical imaging and the only possibility to gain insight into the human brain noninvasively and in-vivo. The applications of this imaging technique are diversified. It is used to study the brain, its structure, development and the functionality of the different areas. Further, important fields of application are neurosurgical planning, examinations of pathologies, investigation of Alzheimer-, strokes, and multiple sclerosis. This thesis gives a brief introduction to MRI and diffusion MRI. Based on this, the mostly used data representation in diffusion MRI in clinical imaging, the diffusion tensor, is introduced. As the diffusion tensor suffers from severe limitations new techniques subsumed under the term HARDI (high angular resolution diffusion imaging) are introduced and discussed in detail. Further, an extensive introduction to tractography, approaches that aim at reconstructing neuronal fibers, is given. Based on the knowledge fromthe theoretical part established tractography algorithms are redesigned to handle HARDI data and, thus, improve the reconstruction of neuronal fibers. Among these algorithms, a novel approach is presented that successfully reconstructs fibers on phantom data as well as on human brain data. Further, a novel global classification approach is presented to cluster voxels according to their diffusion properties.