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Tractography on HARDI data
(2011)
Diffusion weighted imaging is an important modality in clinical imaging and the only possibility to gain insight into the human brain noninvasively and in-vivo. The applications of this imaging technique are diversified. It is used to study the brain, its structure, development and the functionality of the different areas. Further, important fields of application are neurosurgical planning, examinations of pathologies, investigation of Alzheimer-, strokes, and multiple sclerosis. This thesis gives a brief introduction to MRI and diffusion MRI. Based on this, the mostly used data representation in diffusion MRI in clinical imaging, the diffusion tensor, is introduced. As the diffusion tensor suffers from severe limitations new techniques subsumed under the term HARDI (high angular resolution diffusion imaging) are introduced and discussed in detail. Further, an extensive introduction to tractography, approaches that aim at reconstructing neuronal fibers, is given. Based on the knowledge fromthe theoretical part established tractography algorithms are redesigned to handle HARDI data and, thus, improve the reconstruction of neuronal fibers. Among these algorithms, a novel approach is presented that successfully reconstructs fibers on phantom data as well as on human brain data. Further, a novel global classification approach is presented to cluster voxels according to their diffusion properties.
Zusätzlich zum Rendern wird die Rechenleistung moderner Grafikkarten immer häufiger auch für allgemeine Berechnungen (GPGPU) genutzt. Für die Umsetzung stehen verschiedene Möglichkeiten zur Verfügung, die von der Verwendung der Renderingpipeline bis zu eigenständigen Schnittstellen reichen. In dieser Arbeit werden mit Render-To-Texture, Transform Feedback, Compute Shader und OpenCL vier verschiedene GPGPU-Methoden untersucht. Anhand von Partikelsystemen werden sie hinsichtlich der benötigten Berechnungszeit, der GPU-Auslastung, Lines of Code und Portierbarkeit miteinander verglichen. Dazu wurden sowohl das N-Körper Problem, Smoothed Particle Hydrodynamics und ein Partikelschwarm als Partikelsysteme umgesetzt. Es konnte gezeigt werden, dass insbesondere OpenCL und Compute Shader sehr gute Ergebnisse liefern.
This thesis presents a prototypical application for speech therapy as a therapeutical tool, simulating the articulation of German phonemes and the swallowing reflex. A special attention is given to a three-dimensional visualization of anatomical models of the pharyngolaryngeal region, which can be used in an interactive way. For examining the benefits of such an application in relation to conventional therapy mediums, the thesis considers iteratively the requirements of speech therapists.
Die Medizinische Visualisierung komplexer Gefäßbäume hat das Potential den klinischen Alltag in der Gefäßchirurgie zu erleichtern.
Dazu sind exakte, hochaufgelöste Darstellungen und echtzeitfähige Berechnungsmethoden notwendig. Bekannte Ansätze aus den Bereichen der direkten (z.B. Raycasting) und indirekten
(z.B. Marching Cubes) Volumenvisualisierung sind nicht in der Lage alle Anforderungen zufriedenstellend zu erfüllen. Verbesserte
Ergebnisse können mit hybriden Methoden erzielt werden, die unterschiedliche Visualisierungsverfahren kombinieren.
Im Rahmen dieser Arbeit wurde ein hybrides Renderingsystem zur Darstellung von Blutgefäßen entwickelt, das die Bildqualität durch Integration einer Marching Cubes Oberfläche in ein Raycasting–System optimiert, dabei Detailstrukturen erhält und ausreichende Performanz zur Interaktion bietet. Die Ergebnissezeigen die verbesserte Plastizität und Genauigkeit der Darstellung.Anhand von Experten– und Laienbefragungen konnte der Nutzen des Systems vor allem für die Patientenaufklärung nachgewiesen werden. Die Erschließung zusätzlicher Anwendungsgebiete ist durch die Weiterentwicklung des Renderers möglich.
Simulation of fractures
(2014)
Real-time computing often avoids the simulation of fractures due to its complexity. The field of engineering science provides methods to create these simulations to improve games and other applications. Steadily rising computer capacities allow suitable simulations on a real-time basis and make this aspect increasingly interesting. The topic and aim of this research is to simulate fractures of stiff bodies. The primary objective is the physical plausibility and performance of the application. This thesis analyses the potential of computer science to realize the simulation of fractures.
Three existing as well as one self-created were implemented and analysed. The works "Real time simulation of deformation and Fracture of stiff material" from Müller et al., "real time simulation of Brittle Fracture using Modal analysis" from Glondu et al. and "Fast and Controllable simulation of the Shattering of Brittle Objects" from Smith et al. form the basis of this thesis. The introduced methods use different computation of forces and fractures. The developed procedure uses the idea of generating secondary breaks. The approaches were implemented based on the Bullet physics-engine. The results of the work show that physically based breaks are realizable on a real-time basis.
The analysis of the physical methods demonstrates that their performance mainly depends on the constitution of the used objects. This thesis shows that the further investigation of this topic can discover new possibilities. The improvement of the realism in virtual worlds can be achieved by executing physically plausible methods.
Object recognition is a well-investigated area in image-based computer vision and several methods have been developed. Approaches based on Implicit Shape Models have recently become popular for recognizing objects in 2D images, which separate objects into fundamental visual object parts and spatial relationships between the individual parts. This knowledge is then used to identify unknown object instances. However, since the emergence of aσordable depth cameras like Microsoft Kinect, recognizing unknown objects in 3D point clouds has become an increasingly important task. In the context of indoor robot vision, an algorithm is developed that extends existing methods based on Implicit Shape Model approaches to the task of 3D object recognition.
In this thesis, we deal with the question if challenge, flow and fun in computer games are related to each other, and which influence the motivational, psychological components motivation of success, motivation of failure and the chance of success do have. In addition, we want to know if a free choice in the level of difficulty is the optimal way to flow. To examine these theories, a study based on an online survey was executed, in which the participants played the game “flOw“. The results were evaluated with the help of a two-factorial analysis of variance with repeated measurement and tests on correlation. Thereby we found out that there actually exists a relation between challenge, flow and fun and that motivation does matter indirectly.
In current research of the autonomous mobile robots, path planning is still a very important issue.
This master's thesis deals with various path planning algorithms for the navigation of such mobile systems. This is not only to determine a collision-free trajectory from one point to another. The path should still be optimal and comply with all vehicle-given constraints. Especially the autonomous driving in an unknown and dynamic environment poses a major challenge, because a closed-loop control is necessary and thus a certain dynamic of the planner is demanded.
In this paper, two types of algorithms are presented. First, the path planner, based on A*, which is a common graph search algorithm: A*, Anytime Repairing A*, Lifelong Planning A*, D* Lite, Field D*, hybrid A*. Second, the algorithms which are based on the probabilistic planning algorithm Rapidly-exploring Random Tree (Rapidly-exploring Random Tree, RRT*, Lifelong Planning RRT*), as well as some extensions and heuristics. In addition, methods for collision avoidance and path smoothing are presented. Finally, these different algorithms are evaluated and compared with each other.
The mitral valve is one of the four valves in the human heart. It is located in the left heart chamber and its function is to control the blood flow from the left atrium to the left ventricle. Pathologies can lead to malfunctions of the valve so that blood can flow back to the atrium. Patients with a faulty mitral valve function may suffer from fatigue and chest pain. The functionality can be surgically restored, which is often a long and exhaustive intervention. Thorough planning is necessary to ensure a safe and effective surgery. This can be supported by creating pre-operative segmentations of the mitral valve. A post-operative analysis can determine the success of an intervention. This work will combine existing and new ideas to propose a new approach to (semi-)automatically create such valve models. The manual part can guarantee a high quality model and reliability, whereas the automatic part contributes to saving valuable labour time.
The main contributions of the automatic algorithm are an estimated semantic separation of the two leaflets of the mitral valve and an optimization process that is capable of finding a coaptation-line and -area between the leaflets. The segmentation method can perform a fully automatic segmentation of the mitral leaflets if the annulus ring is already given. The intermediate steps of this process will be integrated into a manual segmentation method so a user can guide the whole procedure. The quality of the valve models generated by the method proposed in this work will be measured by comparing them to completely manually segmented models. This will show that commonly used methods to measure the quality of a segmentation are too general and do not suffice to reflect the real quality of a model. Consequently the work at hand will introduce a set of measurements that can qualify a mitral valve segmentation in more detail and with respect to anatomical landmarks. Besides the intra-operative support for a surgeon, a segmented mitral valve provides additional benefits. The ability to patient-specifically obtain and objectively describe the valve anatomy may be the base for future medical research in this field and automation allows to process large data sets with reduced expert dependency. Further, simulation methods that use the segmented models as input may predict the outcome of a surgery.
This master- thesis investigates the topic of intercultural web design. Two websites from different countries are exemplarily compared. On the basis of cultural dimensions, cultural differences are presented on each respective website. The analysis particularly focuses on how detailed the respective website-designer and -operator regards their users" cultural differences and the creation of a cross-cultural web design. The analysis illustrates which cultural - and particularly intercultural - aspects of countries were taken into consideration in the design of the web sites. The investigation led to the conclusion that their implementation was not consequently executed for all web sites. Hence, this thesis offers suggestions for the improvement of aspects which are most important in intercultural web design.