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  • 2015 (1)
  • 2020 (1)

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  • Doctoral Thesis (1)
  • Master's Thesis (1)

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  • Mitral Valve (1)
  • Mitralklappe (1)
  • Segmentation (1)
  • Segmentierung (1)
  • Ultraschall (1)
  • Ultrasound (1)

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Semi-Automatic Segmentation of the Mitral Valve Leaflets on 4D Ultrasound Images (2015)
Lichtenberg, Nils
The mitral valve is one of the four valves in the human heart. It is located in the left heart chamber and its function is to control the blood flow from the left atrium to the left ventricle. Pathologies can lead to malfunctions of the valve so that blood can flow back to the atrium. Patients with a faulty mitral valve function may suffer from fatigue and chest pain. The functionality can be surgically restored, which is often a long and exhaustive intervention. Thorough planning is necessary to ensure a safe and effective surgery. This can be supported by creating pre-operative segmentations of the mitral valve. A post-operative analysis can determine the success of an intervention. This work will combine existing and new ideas to propose a new approach to (semi-)automatically create such valve models. The manual part can guarantee a high quality model and reliability, whereas the automatic part contributes to saving valuable labour time. The main contributions of the automatic algorithm are an estimated semantic separation of the two leaflets of the mitral valve and an optimization process that is capable of finding a coaptation-line and -area between the leaflets. The segmentation method can perform a fully automatic segmentation of the mitral leaflets if the annulus ring is already given. The intermediate steps of this process will be integrated into a manual segmentation method so a user can guide the whole procedure. The quality of the valve models generated by the method proposed in this work will be measured by comparing them to completely manually segmented models. This will show that commonly used methods to measure the quality of a segmentation are too general and do not suffice to reflect the real quality of a model. Consequently the work at hand will introduce a set of measurements that can qualify a mitral valve segmentation in more detail and with respect to anatomical landmarks. Besides the intra-operative support for a surgeon, a segmented mitral valve provides additional benefits. The ability to patient-specifically obtain and objectively describe the valve anatomy may be the base for future medical research in this field and automation allows to process large data sets with reduced expert dependency. Further, simulation methods that use the segmented models as input may predict the outcome of a surgery.
Abstraction of Bio-Medical Surface Data for Enhanced Comprehension and Analysis (2020)
Lichtenberg, Nils
Bio-medical data comes in various shapes and with different representations. Domain experts use such data for analysis or diagnosis, during research or clinical applications. As the opportunities to obtain or to simulate bio-medical data become more complex and productive, the experts face the problem of data overflow. Providing a reduced, uncluttered representation of data, that maintains the data’s features of interest falls into the area of Data Abstraction. Via abstraction, undesired features are filtered out to give space - concerning the cognitive and visual load of the viewer - to more interesting features, which are therefore accentuated. To address this challenge, the dissertation at hand will investigate methods that deal with Data Abstraction in the fields of liver vasculature, molecular and cardiac visualization. Advanced visualization techniques will be applied for this purpose. This usually requires some pre-processing of the data, which will also be covered by this work. Data Abstraction itself can be implemented in various ways. The morphology of a surface may be maintained, while abstracting its visual cues. Alternatively, the morphology may be changed to a more comprehensive and tangible representation. Further, spatial or temporal dimensions of a complex data set may be projected to a lower space in order to facilitate processing of the data. This thesis will tackle these challenges and therefore provide an overview of Data Abstraction in the bio-medical field, and associated challenges, opportunities and solutions.
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