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Statistical Shape Models (SSMs) are one of the most successful tools in 3Dimage analysis and especially medical image segmentation. By modeling the variability of a population of training shapes, the statistical information inherent in such data are used for automatic interpretation of new images. However, building a high-quality SSM requires manually generated ground truth data from clinical experts. Unfortunately, the acquisition of such data is a time-consuming, error-prone and subjective process. Due to this effort, the majority of SSMs is often based on a limited set of this ground truth training data, which makes the models less statistically meaningful. On the other hand, image data itself is abundant in clinics from daily routine. In this work, methods for automatically constructing a reliable SSM without the need of manual image interpretation from experts are proposed. Thus, the training data is assumed to be the result of any segmentation algorithm or may originate from other sources, e.g. non-expert manual delineations. Depending on the algorithm, the output segmentations will contain errors to a higher or lower degree. In order to account for these errors, areas of low probability of being a boundary should be excluded from the training of the SSM. Therefore, the probabilities are estimated with the help of image-based approaches. By including many shape variations, the corrupted parts can be statistically reconstructed. Two approaches for reconstruction are proposed - an Imputation method and Weighted Robust Principal Component Analysis (WRPCA). This allows the inclusion of many data sets from clinical routine, covering a lot more variations of shape examples. To assess the quality of the models, which are robust against erroneous training shapes, an evaluation compares the generalization and specificity ability to a model build from ground truth data. The results show, that especially WRPCA is a powerful tool to handle corrupted parts and yields to reasonable models, which have a higher quality than the initial segmentations.
Die Arbeit befasst sich mit atlasbasierter Segmentierung von CT-Datensätzen mit Hilfe von elastischen Registrierungsmethoden. Ziel ist die vollautomatische Segmentierung eines beliebigen Eingabedatensatzes durch Registrierung mit einem vorsegmentierten Referenzdatensatz, dem Atlanten. Ein besonderes Augenmerk liegt dabei auf der Implementierung und Evaluation elastischer Registrierungsverfahren, da rigide Registrierungsmethoden besonders in Bereichen hoher anatomischer Varianzen keine genaue Segmentierung gewährleisten. Im Vordergrund steht zunächst die Generierung zweier Atlanten, die als durchschnittliche Referenzdatensätze Informationen über die anatomische Varianz männlicher und weiblicher Bevölkerungsgruppen enthalten. Weiter werden vier etablierte elastische Registrierungsarten implementiert und im Hinblick auf eine atlasbasierte Segmentierung der wichtigen Organe des menschlichen Torsos evaluiert: BSpline-Registrierung, Demons-Registrierung, Level-Set-Motion-Registrierung und FEM-Registrierung. Robustheit und Genauigkeit der implementierten Verfahren wurden anhand von Lungen- und Abdomendatensätzen sowohl intra- als auch interpatientenspezifisch ausgewertet. Es wird gezeigt, dass vor allem die elastische BSpline-Registrierung hier genauere Segmentierungsergebnisse liefern kann, als es mit einer rigiden Registrierung möglich ist.
With the emergence of current generation head-mounted displays (HMDs), virtual reality (VR) is regaining much interest in the field of medical imaging and diagnosis. Room-scale exploration of CT or MRI data in virtual reality feels like an intuitive application. However in VR retaining a high frame rate is more critical than for conventional user interaction seated in front of a screen. There is strong scientific evidence suggesting that low frame rates and high latency have a strong influence on the appearance of cybersickness. This thesis explores two practical approaches to overcome the high computational cost of volume rendering for virtual reality. One lies within the exploitation of coherency properties of the especially costly stereoscopic rendering setup. The main contribution is the development and evaluation of a novel acceleration technique for stereoscopic GPU ray casting. Additionally, an asynchronous rendering approach is pursued to minimize the amount of latency in the system. A selection of image warping techniques has been implemented and evaluated methodically, assessing the applicability for VR volume rendering.
Today, augmented reality is becoming more and more important in several areas like industrial sectors, medicine, or tourism. This gain of importance can easily be explained by its powerful extension of real world content. Therefore, augmented realty became a way to explain and enhance the real world information. Yet, to create a system which can enhance a scene with additional information, the relation between the system and the real world must be known. In order to establish this relationship a commonly used method is optical tracking. The system calculates its relation to the real world from camera images. To do so, a reference which is known is needed in the scene to serve as an orientation. Today, this is mostly a 2D-marker or a 2D-texture. These are placed in the real world scenery to serve as a reference. But, this is an intrusion in the scene. That is why it is desirable that the system works without such an additional aid. An strategy without manipulating the scene is object-tracking. In this approach, any object from the scene can be used as a reference for the system. As an object is far more complex than a marker, it is harder for the system to establish its relationship with the real world. That is why most methods for 3D-object-tracking reduce the object by not using the whole object as reference. The focus of this thesis is to research how a whole object can be used as a reference in a way that either the system or the camera can be moved in any 360 degree angle around the object without loosing the relation to the real world. As a basis the augmented reality framework, the so called VisionLib, is used. Extensions to this system for 360 degree tracking are implemented in different ways and analyzed in the scope of this work. Also, the different extensions are compared. The best results were achieved by improving the reinitialization process. With this extension, current camera images of the scene are given to the system. With the hek of these images, the system can calculate the relation to the real world faster in case the relation went missing.
