Statistical Shape Models (SSMs) are one of the most successful tools in 3Dimage analysis and especially medical image segmentation. By modeling the variability of a population of training shapes, the statistical information inherent in such data are used for automatic interpretation of new images. However, building a high-quality SSM requires manually generated ground truth data from clinical experts. Unfortunately, the acquisition of such data is a time-consuming, error-prone and subjective process. Due to this effort, the majority of SSMs is often based on a limited set of this ground truth training data, which makes the models less statistically meaningful. On the other hand, image data itself is abundant in clinics from daily routine. In this work, methods for automatically constructing a reliable SSM without the need of manual image interpretation from experts are proposed. Thus, the training data is assumed to be the result of any segmentation algorithm or may originate from other sources, e.g. non-expert manual delineations. Depending on the algorithm, the output segmentations will contain errors to a higher or lower degree. In order to account for these errors, areas of low probability of being a boundary should be excluded from the training of the SSM. Therefore, the probabilities are estimated with the help of image-based approaches. By including many shape variations, the corrupted parts can be statistically reconstructed. Two approaches for reconstruction are proposed - an Imputation method and Weighted Robust Principal Component Analysis (WRPCA). This allows the inclusion of many data sets from clinical routine, covering a lot more variations of shape examples. To assess the quality of the models, which are robust against erroneous training shapes, an evaluation compares the generalization and specificity ability to a model build from ground truth data. The results show, that especially WRPCA is a powerful tool to handle corrupted parts and yields to reasonable models, which have a higher quality than the initial segmentations.
Mit dem Aufkommen von Head-Mounted Displays (HMDs) der aktuellen Generation erlangt Virtual Reality (VR) wieder großes Interesse im Feld von medizinischer Bildgebung und Diagnose. Exploration von CT oder MRT Daten in raumfüllender Virtual Reality stellt eine intuitive Anwendung dar. Allerdings gilt in Virtual Reality, dass das Aufrechterhalten einer hohen Bildwiederholungsrate noch wichtiger ist als bei konventioneller Benutzerinteraktion, die sitzend vor einem Bildschirm erfolgt. Es existieren starke wissenschaftliche Hinweise, die nahelegen, dass geringe Bildwiederholungsraten und hohe Latenzzeit einen starken Einfluss auf das Auftreten von Cybersickness besitzen. Diese Abschlussarbeit untersucht zwei praktische Ansätze, um den hohen Rechenaufwand von Volumenrendering zu überkommen. Einer liegt in der Ausnutzung von Kohärenzeigenschaften des besonders aufwändigen stereoskopischen Rendering Set-ups. Der Hauptbeitrag ist die Entwicklung und Auswertung einer neuartigen Beschleunigungstechnik für stereoskopisches GPU Raycasting. Zudem wird ein asynchroner Renderingansatz verfolgt, um das Ausmaß von Latenz im System zu minimieren. Eine Auswahl von Image-Warping Techniken wurden implementiert und systematisch evaluiert, um die Tauglichkeit für VR Volumenrendering zu bewerten.